Tadalafil is a drug.

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1. Pharmacological properties

Tadalafil is a drug.

Mechanism for action:

-tadalafil is a selective phosphodiesterase inhibitor-5 (PDE-5). PDE-5 is an enzyme that degrades nitrogen monoxide (no)-cGMP (cyclic monophosphate guanosin) into vascular tissue and smooth muscles of the penis. By inhibiting PDE-5, tadalafil increases the concentration of cGMP, which results in a relaxation of smooth muscles in the penis and allows increased blood flow, facilitating erection.

Pharmacokinetic profile:

-it has a relatively slow but prolonged absorption. Absorption is affected by food intake, but to a lesser extent than other similar drugs. Its time of action is relatively long, with an effect duration that can reach up to 36 hours in some cases, compared to other PDE inhibitors-5 that have a shorter duration.

2. Clinical uses

Treatment of erectile dysfunction (ED):

-it's widely used to treat SD in men. It allows men with DE to get and maintain an erection suitable for satisfactory sexual activity.

Treatment of pulmonary hypertension:

-it has also been investigated and used in some cases for the treatment of pulmonary hypertension. In this case, it works by improving pulmonary hemodynamics by relaxing smooth vascular muscles in the pulmonary vessels, which reduces pulmonary blood pressure.

3. Precautions and side effects

Precautions:

-it should not be used in patients who take nitrates, as the combination can cause a drastic drop in blood pressure, which can be dangerous. In addition, possible interactions with other drugs should be taken into account, and the general cardiovascular health of the patient should be assessed prior to prescription.

Side effects:

-the most common side effects include headache, nasal congestion, back pain, muscle pain, sore throat, and dizziness. These effects are usually mild and transient in most cases.


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