Taladafil: An to the Substance

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The question you want to ask may be "tadalafil".

1. Basic information

Taladafil: An  to the Substance

1、pharmacological effects

- Tadalafil is a selective, reversible inhibitor of cyclic guanosine phosphate (cGMP)-specific phosphodiesterase 5 (PDE5).

- When sexual stimulation leads to the local release of nitric oxide, PDE5 is suppressed by tadalafil, increasing cGMP levels in the corpus cavernosum of the penis, which helps relax smooth muscles and flow into penile tissue, creating an erection.

2、Applicable conditions

- It is mainly used to treat male erectile dysfunction (ED).

- It can also be used to treat pulmonary arterial hypertension (in this case, the trade name is Adcirca), by relaxing pulmonary vascular smooth muscle, reducing pulmonary arterial pressure, improving right ventricular function, etc.

2. Usage and Dosage

1、treatment of erectile dysfunction

- When taken as needed, the recommended starting dose is 10mg, which is taken before sexual intercourse. Depending on individual efficacy and tolerability, the dose can be increased to 20mg or reduced to 5mg.

- When taken once a day, the recommended starting dose is 2.5mg, which is taken at approximately the same time every day. There is no need to consider when to have sex. Depending on the patient's response and tolerance, the dose can be increased to 5mg or reduced to 1.25mg.

2、treatment of pulmonary arterial hypertension

- The usual starting dose is 40mg once daily, which can be adjusted based on patient tolerance.

3. Adverse reactions

1. Common adverse reactions include headache, indigestion, back pain, myalgia, nasal congestion, etc.

2. Some serious but rare adverse reactions may occur, such as vision abnormalities (including blurred vision, color vision changes, etc.), which may be related to the inhibition of retinal PDE6 (although the effect of tadalafil on PDE6 is much weaker than that on PDE5).

4. Matters needing attention

1. Patients who are taking any form of nitrate drugs (such as nitroglycerin, isosorbide dinitrate, etc.) are prohibited from using tadalafil, because the combination of the two may cause a sharp drop in blood pressure, causing serious hypotension and other dangerous situations.

2. Patients with cardiovascular diseases should consult a doctor before using tadalafil, because sexual life itself has certain requirements on the cardiovascular system, and drugs may affect cardiovascular function.

3. For patients with liver and kidney dysfunction, dose adjustment may be necessary.


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